LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease
Identifieur interne : 001C96 ( Main/Exploration ); précédent : 001C95; suivant : 001C97LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease
Auteurs : Carles Vilarino-Güell [États-Unis] ; Christian Wider [Suisse] ; Owen A. Ross [États-Unis] ; Barbara Jasinska-Myga [Pologne] ; Jennifer Kachergus [États-Unis] ; Stephanie A. Cobb [États-Unis] ; Alexandra I. Soto-Ortolaza [États-Unis] ; Bahareh Behrouz [États-Unis] ; Michael G. Heckman [États-Unis] ; Nancy N. Diehl [États-Unis] ; Claudia M. Testa [États-Unis] ; Zbigniew K. Wszolek [États-Unis] ; Ryan J. Uitti [États-Unis] ; Joseph Jankovic [États-Unis] ; Elan D. Louis [États-Unis] ; Lorraine N. Clark [États-Unis] ; Alex Rajput [Canada] ; Matthew J. Farrer [États-Unis]Source :
- Neurogenetics : (Oxford. Print) [ 1364-6745 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Génétique, Neurologie.
English descriptors
- KwdEn :
Abstract
Genetic variation in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was recently associated with an increased risk of developing essential tremor (ET) and Parkinson disease (PD). Herein, we performed a comprehensive study of LINGO1 and its paralog LING02 in ET and PD by sequencing both genes in patients (ET, n=95; PD, n=96) and by examining haplotype-tagging single-nucleotide polymorphisms (tSNPs) in a multicenter North American series of patients (ET, n= 1,247; PD, n=633) and controls (n=642). The sequencing study identified six novel coding variants in LINGO1 (p.S4C, p.V107M, p.A277T, p.R423R, p.G537A, p.D610D) and three in LING02 (p.D135D, p.P217P, p.V565V), however segregation analysis did not support pathogenicity. The association study employed 16 tSNPs at the LINGO1 locus and 21 at the LING02 locus. One variant in LINGO1 (rs9652490) displayed evidence of an association with ET (odds ratio (OR)=0.63; P=0.026) and PD (OR=0.54; P=0.016). Additionally, four other tSNPs in LINGO1 and one in LINGO2 were associated with ET and one tSNP in LING02 associated with PD (P<0.05). Further analysis identified one tSNP in LINGO1 and two in LING02 which influenced age at onset of ET and two tSNPs in LINGO1 which altered age at onset of PD (P<0.05). Our results support a role for LINGO1 and LING02 in determining risk for and perhaps age at onset of ET and PD. Further studies are warranted to confirm these findings and to determine the pathogenic mechanisms involved.
Affiliations:
- Canada, Pologne, Suisse, États-Unis
- Canton de Vaud, Texas, État de New York
- Houston, Lausanne, New York
- Baylor College of Medicine, Université Columbia
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Louis</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Department of Epidemiology, Mailman School of Public Health, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Clark, Lorraine N" sort="Clark, Lorraine N" uniqKey="Clark L" first="Lorraine N." last="Clark">Lorraine N. Clark</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Division of Neurology, Royal University Hospital, University of Saskatchewan</s1><s2>Saskatoon, SK</s2><s3>CAN</s3><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon, SK</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road</s1><s2>Jacksonville, FL 32224</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL 32224</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0470181</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0470181 INIST</idno><idno type="RBID">Pascal:10-0470181</idno><idno type="wicri:Area/PascalFrancis/Corpus">000384</idno><idno type="wicri:Area/PascalFrancis/Curation">000893</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000332</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000332</idno><idno type="wicri:doubleKey">1364-6745:2010:Vilarino Guell C:lingo:and:lingo</idno><idno type="wicri:Area/Main/Merge">001E22</idno><idno type="wicri:Area/Main/Curation">001C96</idno><idno type="wicri:Area/Main/Exploration">001C96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease</title><author><name sortKey="Vilarino Guell, Carles" sort="Vilarino Guell, Carles" uniqKey="Vilarino Guell C" first="Carles" last="Vilarino-Güell">Carles Vilarino-Güell</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road</s1><s2>Jacksonville, FL 32224</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Wider, Christian" sort="Wider, Christian" uniqKey="Wider C" first="Christian" last="Wider">Christian Wider</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, Centre Hospitalier Universitaire Vaudois (CHUV)</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>2 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road</s1><s2>Jacksonville, FL 32224</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Medical University of Silesia</s1><s2>Katowice</s2><s3>POL</s3><sZ>4 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Kachergus, Jennifer" sort="Kachergus, Jennifer" uniqKey="Kachergus J" first="Jennifer" last="Kachergus">Jennifer Kachergus</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road</s1><s2>Jacksonville, FL 32224</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Cobb, Stephanie A" sort="Cobb, Stephanie A" uniqKey="Cobb S" first="Stephanie A." last="Cobb">Stephanie A. Cobb</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road</s1><s2>Jacksonville, FL 32224</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road</s1><s2>Jacksonville, FL 32224</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Behrouz, Bahareh" sort="Behrouz, Bahareh" uniqKey="Behrouz B" first="Bahareh" last="Behrouz">Bahareh Behrouz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road</s1><s2>Jacksonville, FL 32224</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL 32224</wicri:noRegion></affiliation></author><author><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G." last="Heckman">Michael G. Heckman</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Biostatistics Unit, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Biostatistics Unit, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Testa, Claudia M" sort="Testa, Claudia M" uniqKey="Testa C" first="Claudia M." last="Testa">Claudia M. Testa</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Emory Department of Neurology and Center for Neurodegenerative Diseases, Whitehead Biomedical Research Building</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, GA</wicri:noRegion></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>GH Sergievsky Center, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Department of Epidemiology, Mailman School of Public Health, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Clark, Lorraine N" sort="Clark, Lorraine N" uniqKey="Clark L" first="Lorraine N." last="Clark">Lorraine N. Clark</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University</s1><s2>New York, NY</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Division of Neurology, Royal University Hospital, University of Saskatchewan</s1><s2>Saskatoon, SK</s2><s3>CAN</s3><sZ>17 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon, SK</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road</s1><s2>Jacksonville, FL 32224</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL 32224</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurogenetics : (Oxford. Print)</title><title level="j" type="abbreviated">Neurogenetics : (Oxf., Print)</title><idno type="ISSN">1364-6745</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurogenetics : (Oxford. Print)</title><title level="j" type="abbreviated">Neurogenetics : (Oxf., Print)</title><idno type="ISSN">1364-6745</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Essential</term><term>Genetic determinism</term><term>Genetics</term><term>Nervous system diseases</term><term>Neurology</term><term>Parkinson disease</term><term>Tremor</term><term>Variant</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tremblement</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Variant</term><term>Essentiel</term><term>Déterminisme génétique</term><term>Génétique</term><term>Neurologie</term><term>Linkage</term><term>Association génétique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Neurologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic variation in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was recently associated with an increased risk of developing essential tremor (ET) and Parkinson disease (PD). Herein, we performed a comprehensive study of LINGO1 and its paralog LING02 in ET and PD by sequencing both genes in patients (ET, n=95; PD, n=96) and by examining haplotype-tagging single-nucleotide polymorphisms (tSNPs) in a multicenter North American series of patients (ET, n= 1,247; PD, n=633) and controls (n=642). The sequencing study identified six novel coding variants in LINGO1 (p.S4C, p.V107M, p.A277T, p.R423R, p.G537A, p.D610D) and three in LING02 (p.D135D, p.P217P, p.V565V), however segregation analysis did not support pathogenicity. The association study employed 16 tSNPs at the LINGO1 locus and 21 at the LING02 locus. One variant in LINGO1 (rs9652490) displayed evidence of an association with ET (odds ratio (OR)=0.63; P=0.026) and PD (OR=0.54; P=0.016). Additionally, four other tSNPs in LINGO1 and one in LINGO2 were associated with ET and one tSNP in LING02 associated with PD (P<0.05). Further analysis identified one tSNP in LINGO1 and two in LING02 which influenced age at onset of ET and two tSNPs in LINGO1 which altered age at onset of PD (P<0.05). Our results support a role for LINGO1 and LING02 in determining risk for and perhaps age at onset of ET and PD. Further studies are warranted to confirm these findings and to determine the pathogenic mechanisms involved.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Pologne</li><li>Suisse</li><li>États-Unis</li></country><region><li>Canton de Vaud</li><li>Texas</li><li>État de New York</li></region><settlement><li>Houston</li><li>Lausanne</li><li>New York</li></settlement><orgName><li>Baylor College of Medicine</li><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Vilarino Guell, Carles" sort="Vilarino Guell, Carles" uniqKey="Vilarino Guell C" first="Carles" last="Vilarino-Güell">Carles Vilarino-Güell</name></noRegion><name sortKey="Behrouz, Bahareh" sort="Behrouz, Bahareh" uniqKey="Behrouz B" first="Bahareh" last="Behrouz">Bahareh Behrouz</name><name sortKey="Clark, Lorraine N" sort="Clark, Lorraine N" uniqKey="Clark L" first="Lorraine N." last="Clark">Lorraine N. Clark</name><name sortKey="Cobb, Stephanie A" sort="Cobb, Stephanie A" uniqKey="Cobb S" first="Stephanie A." last="Cobb">Stephanie A. Cobb</name><name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G." last="Heckman">Michael G. Heckman</name><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><name sortKey="Kachergus, Jennifer" sort="Kachergus, Jennifer" uniqKey="Kachergus J" first="Jennifer" last="Kachergus">Jennifer Kachergus</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><name sortKey="Testa, Claudia M" sort="Testa, Claudia M" uniqKey="Testa C" first="Claudia M." last="Testa">Claudia M. Testa</name><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Wider, Christian" sort="Wider, Christian" uniqKey="Wider C" first="Christian" last="Wider">Christian Wider</name></region></country><country name="Pologne"><noRegion><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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